Today, experts don’t know why this happens
Madrid After vaccination with AstraZeneca and Johnson & Johnson, the development of blood clots in the brain and other organs seems to have a greater impact on women under 60. Today, experts do not know exactly why this phenomenon occurs, although there are many factors that can explain part of this phenomenon, published by El País.
After receiving Janssen vaccination in the United States, all six thrombosis patients were women. After understanding these conditions, the US Department of Pharmacology recommended that the injection be stopped for vaccination. Johnson & Johnson, the vaccine company, has suspended distribution in Europe.
Using the AstraZeneca vaccine, until March 4, the European Medicines Agency (EMA) had detected 222 thrombus cases among 35 million vaccinations, and more or less 1 case was found after every 175,000 vaccinations, which is very low The incidence rate. Also in this case, most of the affected are relatively young women. According to data from last Friday, more than 2.5 million people in Spain have been vaccinated with AstraZeneca, and 12 cases are currently being studied. It is also necessary to add a portrait of a man from Castilla-La Mancha whose death after vaccination is under study.
This thrombosis is characterized by a sudden drop in platelets
Two medical teams from Germany and Austria have just clarified the occurrence of blood clots in people vaccinated with AstraZeneca. In all cases, this is a reaction in which the immune system targets the patient and produces antibodies that selectively bind to platelet surface proteins. These blood cells are responsible for blood clotting. When the antibody binds to this protein called platelet factor 4, the platelets are activated and begin to bind to each other, creating a blood clot. Of the 11 patients analyzed in Germany and Austria, 9 were women. Most people have blood clots in the brain or abdominal blood vessels. In Germany and Austria, the first two cases occurred in two female health workers aged 49 and 37.
0 This thrombosis is characterized by a sudden drop in platelets. The conditions observed after vaccination are very similar to the very rare reactions that have been observed in patients treated with the anticoagulant heparin.
At present, the cause of autoimmune reaction after vaccination is not known. Presumably, this may be due to the types of vehicles used in AstraZeneca and Janssen vaccines: two adenoviruses. The first uses an inactivated chimpanzee adenovirus, and the second uses a banned human adenovirus.
There are at least two other approved vaccines that also use adenovirus, the Russian satellite and China’s Cansino. So far, there has been no warning that they will cause thrombosis, but there have been two injections from countries with opaque vaccination data. “Today, we cannot obtain information about the adverse effects of these two vaccines,” explained Federico Martin Torres, director of pediatrics at the University of Santiago de Compostela in Santiago and member of the WHO Vaccine Advisory Committee.
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It is not clear why blood clots affect young women more, but there are some factors that may help explain this. Rodrigo Rial, spokesperson for the Spanish Vascular Surgery Association, explained that, first of all, women suffer from more autoimmune diseases than men, and at younger ages, the more active their immune systems are, the more likely they are to be affected by this complication. . The doctor added another risk factor that only affects certain young women: birth control pills slightly increase the risk of blood clots. The risks associated with birth control pills far outweigh the risks of vaccination. The latest data from the European Medicines Agency shows that about one in every thousand women taking birth control pills suffers from this kind of clot, and the risk of vaccination is one in 175,000.
For patients with a poor response to heparin, there is already a possible treatment: stop the anticoagulant and give gamma globulin
Martinón-Torres explained that under normal circumstances, sinus thrombosis is the most common type in people who are vaccinated by AstraZeneca and Janssen, and it is more common in women in their 30s, with three quarters of them Was recorded.
In addition to these factors, who else is vaccinating AstraZeneca is usually a prejudice among people under the age of 60, so more cases may be seen in women.
One of the problems is that there are no known markers to tell who will experience this very rare side effect. There is indeed a possible treatment method that has been used in patients who have a poor response to heparin: stop the administration of this anticoagulant and give a blood protein, gamma globulin.
All the experts consulted agreed that the very rare appearance of these clots would not affect the vaccination process.