Compared to following a standard vaccination schedule, the combination of the covid-19 vaccine causes mild and moderate side effects more frequently.
Mexico City (APRO). -Compared with following a standard vaccination schedule (two injections of the same drug), the combined use of vaccines against covid-19 will have mild and moderate side effects.
The preliminary results of a study conducted by experts at the University of Oxford clearly show this, and the report was published this week by the professional journal The Lancet.
According to the text, the investigation began at the beginning of this year with the purpose of investigating the effects of the combination of two-dose preparations produced by different pharmaceutical companies and found that it increased the common side effects of the vaccine, such as cold at the application site, fever, muscle pain and fatigue.
In addition, they found that the combination of drugs (Pfizer-BionNTech, followed by Oxford-AstraZeneca and Oxford-AstraZeneca, and then Pfizer-BioNTech) was applied after the second dose at a four-week interval between the two doses. ) Will produce a milder or moderate response after the second dose instead of following the standard procedure of not combining different inoculums.
Similarly, experts also reported that the adverse effects of combining two drugs from different manufacturers were short-lived and clarified that no other safety-related issues were found.
Although this is a secondary part of what we are trying to explore through these studies, it is important that we inform people of these data, especially since multiple countries are considering using these mixed-dose schedules, the University of Oxford Pediatrics and Vaccines Laboratory The director is also the lead researcher of the study.
The hematological and biochemical characteristics between the heterologous and homologous vaccination regimens are similar. The severity of all laboratory adverse events in the heterologous vaccination regimen is grade 2 or lower, and there is no group in any group on the 7th day after vaccination. Thrombocytopenia. The research was published in The Lancet.
The experts also pointed out that the data they collected from the test came from participants over the age of 50, so they believe that these reactions may be more common in younger age groups.
The findings of this study indicate: “The mixed-dose schedule may lead to an increase in absenteeism on the second day after immunization, so this must be considered when planning immunizations for healthcare workers,” he added Snape.
However, these conclusions are incomplete. The final conclusions on efficacy or safety work will be ready after June. The reason is that almost half of the 830 volunteers recruited will receive the second dose 84 days after the first dose.
The data published in The Lancet is based on preliminary results from the vaccine in the other half of the vaccine, which received two doses within 28 days.