In the past 100 years, life expectancy has increased dramatically all over the world
Mexico City- In the past 100 years, life expectancy worldwide has greatly increased, from 50 to 70 years or more, mainly due to improvements in hygiene and sanitation, vaccination and lifestyle.
Therefore, today, there are 1 billion people over 60 years old in the world. Expert Margaretta Colangelo estimates that this population will continue to grow until it reaches the point where there are more elderly than young for the first time in history.
In view of this, a huge challenge is obvious: how to ensure that these people not only live long, but also do not suffer from diseases that usually increase with age (such as Alzheimer’s disease, osteoporosis, kidney disease and cardiovascular disease) survive?
Colangelo, co-author of the book “Longevity Industry”, said: “People’s life expectancy can sometimes reach 72 years, but in some countries, because people are sick and hospitalized, the last 10 years of it are unhealthy.” 1.0: Define human history The largest and most complex industry in the world.
A science and technology-based company that aims to promote the development of drugs and anti-aging therapies (such as so-called senolytics).
Moreover, one of the consequences of aging is the accumulation of senescent cells: normal cells that stop dividing will promote tissue aging and secrete substances such as cytosine that cause inflammation. The latter has been identified as an important factor related to diseases such as heart disease, diabetes, cancer, arthritis, depression and Alzheimer’s disease.
Colangelo refers to work carried out in places such as the Mayo Clinic. For example, a study on obese mice showed that the combination of two drugs, daartinib and quercetin, killed senescent cells. And restore the growth of cells in the brain.
The expert cited the work of biotechnology company Insilico Medicine as an example. In this field, technological advances in artificial intelligence (AI) will make it increasingly possible to discover potential anti-aging drugs and treatments faster.
“Usually, when we try to find a drug to treat a certain disease, it’s like looking for a needle in a haystack. It takes 10 to 20 years to find a drug that doesn’t even work. So it’s very difficult. “Colangelo has more than 30 years of experience in the leadership of software companies in Silicon Valley and is the co-founder and CEO of Jthereum.
“So what Insilico Medicine did is they didn’t use a haystack to find a needle, but used AI to design the perfect needle, and they have successfully done it. In fact, they were able to identify potential drugs within 45 days., Yes In September 2019. This is the first time that a drug candidate has been quickly found.”
Therefore, many of these developments do not need to wait 10 years, but only two years to be ready, and the price may be lower.
Colangelo said that this is not only a problem of artificial intelligence, but also involves the implementation of the same messenger RNA technology used in some SARS-CoV-2 vaccines and even nanomedicine.
“For example, there is a company called NaNotics that uses attractive nanoparticles injected into the human body to help the human body get rid of senescent cells. It is not a drug, so it has no side effects and does not affect the human body. Drugs can do the way.
He said: “These are called third wave treatments, many of which will not cause harm to the body, which will be very, very good and can be obtained in just four years.” Animal clinics are close to humans.
In addition to all the above-mentioned functions, biomarkers will also play an important role. For example, a biomarker recently discovered by researchers at the Barker Institute, which is “the world’s number one in aging research”, proves that Colangelo- is qualified. Yes, when the senescent cells are released, Colangelo- is ready to use. They were forced to die and were detectable in blood and urine.
This allows non-invasive testing to measure and track aging performance.
Just like what happened in the current health emergency, as world regulators speed up the process of releasing the Covid-19 vaccine to the world, Colangelo hopes to repeat this process in the longevity industry.
“We also hope that they also receive longevity therapy. We don’t want to wait 10 years, we want them to do what they have to do. Obviously, take all necessary steps, but if they can cut expenses, a little red tape and paperwork can speed up Longevity treatment.”
Experts emphasize that in this way, many unnecessary sufferings can save thousands of people. This is the ultimate goal of the industry, not just seeking to extend life.
“People usually say:’Oh, this will help people live longer; maybe we can live 120 years.’ And I would rather think: How many people will not have to suffer? I think it’s important to look at this in this way.
“We don’t have to see parents suffering from Alzheimer’s disease and dementia or stroke. They can live healthily without suffering. This may be the first time in human history that parents do not need to be tortured.” Emphasis.
“This is the most positive thing that has happened on Earth: anti-lifetime research.”
Margaretta Colangelo speculates that these new medicines and therapies may be in the hands of everyone, because they will take such measures as soon as possible in the next five years and have no choice but to follow basic care measures : Eat a healthy diet, exercise regularly, avoid overeating to reduce weight, reduce stress and get enough sleep.
Experts say: “There are many people in the world who work under pressure, which leads to the entire cycle of disease. This does cause inflammation.”
In particular, the factor that may severely affect life expectancy is Covid-19 itself, and attention should be paid at this time, because about 50 persistent sequelae have been listed among the infected.
From chronic fatigue, headaches and lung diseases to high blood pressure and many neurological events.
Colangelo reiterated: “Many times, Covid affects the heart or brain, and people may suffer from early dementia or neurological diseases.”
“Kidney failure may also occur; many people with Covid need dialysis. Therefore, people may have heart or kidney problems, which will cost them their lives for life.”
However, even simple events such as continuous insomnia for those who have defeated the coronavirus can have very harmful effects because sleep is one of the important aspects of longevity.
Experts insist: “We should have 8 hours of sleep every night, and those who sleep regularly are longer. This is very important for health.”
“If Covid is another problem that bothers insomnia, then reduce it. When someone says’I have insomnia,’ it doesn’t look as serious as a cardiac arrest or a stroke. But in the long run, if If you don’t do this, you will not sleep well and you may encounter various problems.”
Colangelo is particularly fascinated by the impact of the social environment on longevity, especially since Mexico has the largest number of people over the age of 100 living with their families-95%-while in other countries, most centenarians It is -60%-in nursing homes.
“This is amazing! This can help those people stay healthy, especially during the Covid-19 pandemic.
“People living in nursing homes in emergency situations are very vulnerable. First, because of the disease itself, and because they can’t see anyone for a whole year; they can’t see their families, they are very, very, very, very, very Human care is the most prominent,” he admitted.
Finally, Colangelo recently participated in the 2021 Innovation Week event organized by the Mexican Pharmaceutical Research Industry Association (AMIIF). He also highlighted that Mexico is one of the countries with the highest average retirement age in the world due to 46% of men. And 50% of men and women continue to work after the age of 65.
Even a quarter of men over 80 are still working. Therefore, enabling them to receive longevity therapy can enable them to have greater functions; “They are already 80 years old, but biologically speaking, they will be in a situation of around 50 years old,” Colangelo emphasized at Innovation Week.
He said: “If the (Mexico) government recognizes earlier that it will make more people live longer in 10 or 20 years, it can formulate public policies to help the people, and it can save a lot of medical expenses.”
Margaretta Colangelo’s experience as a member of the advisory board of multiple committees (such as Novartis), or the experience of closely talking with scientists and disseminating the results of their research, is absolutely full of something. Confidence: The future will be better than the present, anyone expects.
Experts said: “This will be better because we will have incredible technology. The technology is so good that these companies ranked number one will become the most valuable companies in the history of mankind. But they will also The largest number of people provide help.”.
“Usually, drug development is aimed at people with specific diseases such as cancer or cardiovascular disease. However, everyone’s age is increasing, and everyone in the existing 7 billion population is aging. Therefore, this information It’s important for people of all ages. It’s very positive.”
He believes that most people do not understand the impact of technology, and the impact of technology can usually turn bad things into very good.
“Many people who work in technology want to share it with the world. Therefore, it is important to understand that this does not only apply to Silicon Valley people or billionaires. No, many of these scientists want everyone on every continent to share it. You can use it,” he said.
All that needs to be done is to allocate resources correctly?
The most important thing in the world is not money, but the way to gain knowledge. If everyone spends a little time learning technology and science, they can update their mindset and understand that the situation is changing.
99% of the people in the world have not absorbed us and we are in the midst of a huge scientific revolution.
Therefore, the most important thing is that humans begin to read about technology: what is AI, what is quantum computing, and what is Messenger RNA.
Moreover, he explained that when reading articles about technology, they may start to feel more comfortable with technology and thus give up some beliefs.
“I think many people worry that artificial intelligence will harm us. No, cancer will harm us; artificial intelligence will help us defeat cancer.
He concluded: “In any case, the world will be very surprised when they see how beautiful the future is.”