One of the largest reports strengthens the evidence
One of the most extensive reports of coronavirus vaccination during pregnancy further proves that it is safe to do so, even if the author believes that a more comprehensive investigation is necessary.
The preliminary results are based on data from more than 35,000 American women who received Moderna or Pfizer vaccines during pregnancy.
The incidence of unexplained miscarriage, preterm birth and other complications is comparable to the incidence in pre-pandemic pregnancy reports.
New evidence from researchers at the Centers for Disease Control and Prevention (CDC) was published in the New England Journal of Medicine on Wednesday.
None of the participants received a single-dose vaccine from Johnson & Johnson, which was unavailable before the study, and is currently awaiting reports of a small number of women with blood clots.
For its part, the American Society for Reproductive Medicine passed evidence that had been examined for more than a year on Tuesday and approved vaccination during pregnancy.
“Everyone, including pregnant women and those planning to become pregnant, should be vaccinated against COVID-19. The association said in a statement that the vaccine is safe and effective.
A representative of the association said that the association has not yet evaluated the latest evidence on Johnson & Johnson vaccine.
A representative of the American College of Obstetricians and Gynecologists said the CDC report is promising, but pointed out that long-term follow-up is needed. The team has previously said that both pregnant women and breastfeeding mothers should be vaccinated, and many pregnant women choose to be vaccinated.
Although pregnant women are excluded from studies where vaccines can be used urgently, there is evidence that there is no harm to these people without knowing that they are giving birth.
Dr. Laura Riley, director of obstetrics and gynecology at Weill Cornell University in New York, said the results are reassuring.
He said: “It’s great to be able to share data with patients who continue to weigh the risks and benefits of vaccination.” “They know that complications of COVID infection may occur during pregnancy, and now there is some information about the safety of human pregnancy.”
Pregnant women infected with the coronavirus face a high risk of complications, such as intensive care unit, premature delivery and death.
The authors of the study, led by Dr. Tom Shimabukuro of the CDC, said that continued follow-up is needed and more evidence is needed, including women who have been vaccinated early in pregnancy.
Their study included information on 35,691 American pregnant women who participated in the voluntary telephone vaccine surveillance system and received Moderna or Pfizer vaccines between mid-December and the end of February 2020.
It also includes reports of pregnancy complications from nearly 4,000 women registered in the US Vaccine Safety Registry. Among them, there were 712 live births, accounting for 86%, mainly among women who were vaccinated in the third trimester.
Most women in this group reported pain at the injection site, but severe reactions rarely occurred. Obviously, pregnant women are prone to pain when using both vaccines, but compared with non-pregnant women, other reactions are less likely.
In the vaccine registration, about 13% of pregnant women have unexplained miscarriages, less than 1% of stillbirths, 9% of premature births, and 2% of infants with congenital abnormalities. These rates are similar to those observed in reports of pregnant women before the pandemic.